Question: Why is dexamethasone given in pregnancy?

Conclusion: Dexamethasone accelerates maturation of fetal lungs, decrease number of neonates with respiratory distress syndrome and improves survival in preterm delivered neonates. Optimal gestational age for use of dexamethasone therapy is 31 to 34 weeks of gestation.

Is dexamethasone safe during pregnancy?

Dexamethasone and betamethasone cross the placenta with similar maternal and fetal concentrations; thus, they are the treatment of choice for fetal respiratory distress. The lowest possible steroid dose needed to control disease activity should be used in pregnancy.

How is dexamethasone administered during pregnancy?

A standard regimen of dexamethasone that comprised two doses of 12-mg intramuscular injections, 12 h apart was administered to 12 pregnant women to promote fetal lung maturation in anticipation of premature delivery before 34 completed weeks of gestation.

Why do they give you steroids during pregnancy?

If a baby is at risk of being born too early, giving the mother steroids before the birth can help her unborn baby’s lungs to develop more quickly. This reduces the risk of serious complications or the newborn dying. Preterm birth is when a baby is born before 37 completed weeks of pregnancy.

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How does dexamethasone mature fetal lungs?

Antenatal steroids (dexamethasone or betamethasone) can cross the placenta to mature the fetal lung and brain. In the lung, antenatal steroids can decrease the fetal lung fluid through activation of ENaCs, induce the production of surfactant proteins and lipid synthesis, and alter preterm responses to oxidative stress.

When is dexamethasone given in pregnancy?

Conclusion: Dexamethasone accelerates maturation of fetal lungs, decrease number of neonates with respiratory distress syndrome and improves survival in preterm delivered neonates. Optimal gestational age for use of dexamethasone therapy is 31 to 34 weeks of gestation.

What are the side effects of dexamethasone in pregnancy?

No serious side effects have been reported after administration of corticosteroids during pregnancy, but some studies reported reduction in fetal body movements, fetal breathing movements and heart rate variation after betamethasone administration (4), (5).

When are steroids given in pregnancy?

A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation, and may be considered for pregnant women starting at 23 0/7 weeks of gestation who are at risk of preterm delivery within 7 days 1 11 13.

What are the contraindications of dexamethasone?

Who should not take DEXAMETHASONE?

  • active, untreated tuberculosis.
  • inactive tuberculosis.
  • herpes simplex infection of the eye.
  • a herpes simplex infection.
  • an infection due to a fungus.
  • intestinal infection caused by the roundworm Strongyloides.
  • a condition with low thyroid hormone levels.
  • diabetes.

At what week are baby’s lungs fully developed?

By 36 weeks, your baby’s lungs are fully formed and ready to take their first breath after the birth. The digestive system is fully developed and your baby will be able to feed if they’re born now.

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Do steroid injections make baby more active?

Some people go into labor very early. If you deliver before 34 weeks, receiving corticosteroid injections can improve your baby’s chances of doing well. These help the baby’s lungs to function. Steroids are usually injected into one of the large muscles (arms, legs, or buttocks) of the pregnant person.